Although much is known about the performance of recent methods for inference and interval estimation for indirect or mediated effects with observed variables, little is known about their performance in latent variable models. This article presents an extensive Monte Carlo study of 11 different leading or popular methods adapted to structural equation models with latent variables. Manipulated variables included sample size, number of indicators per latent variable, internal consistency per set of indicators, and 16 different path combinations between latent variables. Results indicate that some popular or previously recommended methods, such as the bias-corrected bootstrap and asymptotic standard errors had poorly calibrated Type I error and coverage rates in some conditions. Likelihood-based confidence intervals, the distribution of the product method, and the percentile bootstrap emerged as leading methods for both interval estimation and inference, whereas joint significance tests and the partial posterior method performed well for inference.