Susana G. Sotocinal, M.Sc.

Research Associate

Director of Phenomics

  • Mogil, J.S., Miermeister, F., Seifert, F., Strasburg, K., Zimmermann, K., Reinold, H., Austin, J.-S., Bernardini, N., Chesler, E.J., Hofmann, H.A., Hordo, C., Messlinger, K., Nemmani, K.V., Rankin, A.L., Ritchie, J., Siegling, A., Smith, S.B., Sotocinal, S.G., Vater, A., Lehto, S.G., Klussmann, S., Quirion, R., Michaelis, M., Devor, M., and Reeh, P.W.  Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc. Natl. Acad. Sci., U.S.A., 102:12938-12943, 2005.
  • Langford, D.J., Crager, S.E., Shehzad, Z., Smith, S.B., Sotocinal, S.G., Levenstadt, J.S., Chanda, M.L., Levitin, D.J., and Mogil, J.S.  Social modulation of pain as evidence for empathy in mice.  Science, 312:1967-1970, 2006.
  • Mogil, J.S., Ritchie, J., Sotocinal, S.G., Smith, S.B., Croteau, S., Levitin, D.J., and Naumova, A.K.  Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays.  Pain, 126:24-34, 2006.
  • Smith, S.B., Marker, C.L., Perry, C., Liao, G., Sotocinal, S.G., Austin, J.-S., Melmed, K., Clark, D.J., Peltz, G., Wickman, K., and Mogil, J.S.  Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. Pharmacogenet. Genom.,18:231-242, 2008.
  • LaCroix-Fralish, M.L., Mo, G., Smith, S.B., Sotocinal, S.G., Ritchie, J., Austin, J.-S., Melmed, K., Schorscher-Petcu, A., Laferriere, A., Lee, T.H., Romanovsky, D., Liao, G., Behlke, M.A., Clark, J.D., Peltz, G., Seguela, P., Dobretsov, M., and Mogil, J.S.  The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.  Pain, 144:294-302, 2009.
  • Langford, D.J., Tuttle, A.H., Brown, K., Deschenes, S., Fischer, D.B., Mutso, A., Root, K.C., Sotocinal, S.G., Stern, M.A., Mogil, J.S., and Sternberg, W.F.  Social approach to pain in laboratory mice.  Soc. Neurosci., 5:163-170, 2010.
  • Langford, D.J., Bailey, A.L., Chanda, M.L., Clarke, S.E., Drummond, T.E., Echols, S., Glick, S., Ingrao, J., Klassen-Ross, T., LaCroix-Fralish, M.L., Matsumiya, L., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wong, D., van den Maagdenberg, A.M.J.M., Ferrari, M.D., Craig, K.D., and Mogil, J.S. Coding of facial expression of pain in the laboratory mouse.  Nat. Meth., 7:447-449, 2010.
  • Schorscher-Petcu, A., Sotocinal, S.G., Ciura, S., Dupre, A., Ritchie, J., Sorge, R.E., Crawley, J.N., Hu, S.-B., Nishimori, K., Young, L.J., Tribollet, E., Quirion, R., and Mogil, J.S. Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse.  J. Neurosci., 30:8274-8284, 2010.
  • Fortin, A., Diez, E., Ritchie, J., Sotocinal, S.G., Dube, M.-P., Gagne, M., Paquette, O., Skamene, E., and Mogil, J.S. Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1(tyrosinase-related protein 1).  Genes Brain Behav., 9:856-867, 2010.
  • Sotocinal, S.G., Sorge, R.E., Zaloum, A., Tuttle, A.H., Martin, L.J., Wieskopf, J.S., Mapplebeck, J.C.S., Wei, P., Zhan, S., Zhang, S., McDougall, J.J., King, O.D., and Mogil, J.S.  The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions.  Mol. Pain, 7:55, 2011.
  • Matsumiya, L.C., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wieskopf, J.S., Zaloum, A., King, O.D., and Mogil, J.S.  Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. J. Am. Assoc. Lab. Anim. Sci., in press.
  • Matsumiya, L.C., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wieskopf, J.S., Zaloum, A., King, O.D., and Mogil, J.S.  Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. J. Am. Assoc. Lab. Anim. Sci., 51:42-49, 2012.
  • Mogil, J.S., Sorge, R.E., LaCroix-Fralish, M.L., Smith, S.B., Fortin, A., Sotocinal, S.G., Ritchie, J.R., Austin, J.-S., Schorscher-Petcu, A., Melmed, K., Czerminski, J., Bittong, R.A., Mokris, J.B., Neubert, J.K., Campbell, C.M., Edwards, R.R., Campbell, J.N., Crawley, J.N., Lariviere, W.R., Wallace, M.R., Sternberg, W.F., Balaban, C.D., Belfer, I., and Fillingim, R.B. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat. Neurosci., 14:1569-1573, 2011.
  • Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Sotocinal, S.G., Austin, J.-S., Ritchie, J., Chanda, M.L., Graham, A.C., Topham, L., Beggs, S., Salter, M.W., and Mogil, J.S.  Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice.  J. Neurosci., 31:15450-15454, 2011.
  • Shekarabi, M., Moldrich, R., Rasheed, S., Salin-Cantegrel, A., Laganiere, J., Rochesfort, D., Hince, P., Huot, K., Gaudet, R., Kurniawan, N., Sotocinal, S.G., Ritchie, J., Dion, P., Mogil, J.S., Richards, L., and Rouleau, G. Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum. J. Neurosci., 32:3865-3876, 2012.
  • Malfait, A.M., Seymour, A.B., Gao, F., Tortorella, M.D., Hellio Le Graverand-Gastineau, M.P., Wood, L.S., Doherty, M., Doherty, S., Zhang, W., Arden, N.K., Vaughn, F.L., Leaverton, P.E., Spector, T.D., Hart, D.J., Maciewicz, R.A., Muir, K.R., Das, R., Sorge, R.E., Sotocinal, S.G., Schorscher-Petcu, A., Valdes, A.M., and Mogil, J.S.  A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.  Ann. Rheum. Dis., 71:1042-1048, 2012.
  • Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Khoutorsky, A., Sotocinal, S.G., Austin, J.-S., Melmed, K., Labialle, S., Schmidt, J.V., Wood, J.N., Naumova, A.K., and Mogil, J.S. The yin and yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene.Genes, Brain and Behavior, 12:405-413, 2013.
  • Sorge, R.E., Martin, L.J., Isbester, K.A., Sotocinal, S.G., Rosen, S., Tuttle, A.H., Wieskopf, J.S., Acland, E.L., Dokova, A., Kadoura, B., Leger, P., Mapplebeck, J.C.S., McPhail, M., Delaney, A., Wigerblad, G., Schumann, A.P., Quinn, T., Frasnelli, J., Svensson, C.I., Sternberg, W.F., and Mogil, J.S.  Olfactory exposure to males, including human males, stresses rodents.  Nat. Meth., 11:629-632, 2014.
  • Szabo, N.E., da Silva, R.V., Sotocinal, S.G., Zeilhofer, H.U., Mogil, J.S., and Kania, A.  Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity and nociception.  J. Neurosci., 35:5233-5246, 2015.
  • Sorge, R.E., Mapplebeck, J.C.S., Rosen, S., Beggs, S., Taves, S., Alexander, J.K., Martin, L.J., Austin, J.-S., Sotocinal, S.G., Chen, D., Yang, M., Shi, X.Q., Huang, H., Pillon, N.J., Bilan, P.J., Tu, Y., Klip, A., Ji, R.-R., Zhang, J., Salter, M.W. and Mogil, J.S.  Different immune cells mediate mechanical pain hypersensitivity in male and female mice.  Nat. Neurosci., 18:1081-1083, 2015.
  • Kahle, K.T., Schmouth, J.F., Lavastre, V., Latremoliere, A., Zhang, J., Andrews, N., Omura, T., Laganiere, J., Rochefort, D., Hince, P., Castonguay, G., Gaudet, R., Mapplebeck, J.C., Sotocinal, S.G., Duan, J., Ward, C., Khanna, A.R., Mogil, J.S., Dion, P.A., Woolf, C.J., Inquimbert, P., and Rouleau, G.A.  Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.  Sci. Signal. 9:ra32, 2016. 
  • Parisien, M., Khoury, S., Chabot-Dore, A.-J., Sotocinal, S.G., Slade, G.D., Smith, S.B., Fillingim, R.B., Ohrbach, R., Greenspan, J.D., Maixner, W., Mogil, J.S., Belfer, I., and Diatchenko, L.  Effect of human genetic variability on gene transcription in dorsal root ganglia and association with pain phenotypes.  Cell Rep., 19:1940-1952, 2017.
  • Martin, L.J., Smith, S.B., Khoutorsky, A., Magnussen, C.A., Samoshkin, A., Sorge, R.E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khong, T.M., Mir, E., Gibson, D.G., Wieskopf, J.S., Sotocinal, S.G., Austin, J.-S., Meloto, C.B., Gitt, J.H., Gkogkas, C., Sonenberg, N., Greenspan, J., Fillingim, R.B., Ohrbach, R., Slade, G.D., Knott, C., Dubner, R., Nackley, A.G., Ribeiro-da-Silva, A., Neely, G.G., Maixner, W., Zaykin, D.V., Mogil, J.S., and Diatchenko, L.  Epiregulin and EGFR interactions are involved in pain processing.  J. Clin. Invest., 127:3353-3363, 2017.
  • Tuttle, A.H., Molinaro, M.J., Jethwa, J.F., Sotocinal, S.G., Prieto, J.C., Styner, M.A., Mogil, J.S., and Zylka, M.J.  A deep neural network to assess spontaneous pain from mouse facial expressions.  Mol. Pain 14:1-29, 2018.
  • Tansley, S.N., Tuttle, A.H., Wu, N., Tohyama, S., Dossett, K., Gerstein, L., Ham, B., Austin, J.-S., Sotocinal, S.G., and Mogil, J.S.  Modulation of social behavior and dominance status by chronic pain in mice.  Genes Brain Behav., 18:e12514, 2019.
  • Tansley, S.N., Macintyre, L.C., Diamond, L., Sotocinal, S.G., George, N., Meluban, L., Austin, J.-S., Coderre, T.J., Martin, L.J., and Mogil, J.S.  Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity.  Pain, 160:784-792, 2019.
  • Petitjean, H., Bourojeni, F.B., Tsao, D., Davidova, A., Sotocinal, S.G., Mogil, J.S., Kania, A., and Sharif-Naeini, R.  Recruitment of spinoparabrachial neurons by dorsal horn calretinin neurons.  Cell Rep., 28:1429-1438, 2019.
  • Muralidharan, A., Sotocinal, S.G., Austin, J.-S., and Mogil, J.S.  The influence of aging and duration of injury on the anti-allodynic efficacy of analgesics in laboratory mice.  Pain Rep., 5:e824, 2020.
Research Associate

Director of Phenomics

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Department of Psychology 
McGill University 
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