Jeffrey Wieskopf, A.B.D. (McGill University)

Graduate Student

Role of Nicotinic Receptors in Pain

Currently a psychiatry resident at University of Toronto.

  • Sotocinal, S.G., Sorge, R.E., Zaloum, A., Tuttle, A.H., Martin, L.J.,Wieskopf, J.S., Mapplebeck, J.C.S., Wei, P., Zhan, S., Zhang, S., McDougall, J.J., King, O.D., and Mogil, J.S. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol. Pain, 7:55, 2011.
  • Matsumiya, L.C., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wieskopf, J.S., Zaloum, A., King, O.D., and Mogil, J.S.  Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice.  J. Am. Assoc. Lab. Anim. Sci., 51:42-49, 2012.
  • Tsao, D., Wieskopf, J.S., Rashid, N., Sorge, R.E., Segall, S.K., Mogil, J.S., Maixner, W., Dokholyan, N.V., and Diatchenko, L.  Serotonin-induced hypersensitivity via inhibition of catechol-O-methyltransferase activity. Mol. Pain, 8:25, 2012.
  • Corder, G., Doolen, S., Donahue, R.R., Winter, M.K., Jutras, B.L., He, Y., Hu, X., Wieskopf, J.S., Mogil, J.S., Storm, D.R., Wang, Z.J., McCarson, K.E., and Taylor, B.K.  Constitutive m-opioid receptor activity leads to long-term endogenous analgesia and dependence.  Science, 341:1394-1399, 2013.
  • Daou, I., Tuttle, A.H., Long, G., Wieskopf, J.S., Bonin, R., Ase, A., Wood, J.N., De Koninck, Y., Ribeiro-da-Silva, A., Mogil, J.S., and Seguela, P.  Remote optogenetic activation and sensitization of pain pathways in freely moving mice.  J. Neurosci., 33:18631-18640, 2013.   
  • Sorge, R.E., Martin, L.J., Isbester, K.A., Sotocinal, S.G., Rosen, S., Tuttle, A.H., Wieskopf, J.S., Acland, E.L., Dokova, A., Kadoura, B., Leger, P., Mapplebeck, J.C.S., McPhail, M., Delaney, A., Wigerblad, G., Schumann, A.P., Quinn, T., Frasnelli, J., Svensson, C.I., Sternberg, W.F., and Mogil, J.S.  Olfactory exposure to males, including human males, stresses rodents.  Nat. Meth., 11:629-632, 2014.
  • Wieskopf, J.S., Pan, Y.-X., Marcovitz, J., Tuttle, A.H., Majumdar, S., Pidakala, J., Pasternak, G.W., and Mogil, J.S. Broad spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene. Pain, 155:2063-2070, 2014.
  • Wieskopf, J.S., Mathur, J., Limapichat, W., Post, M.R., Al-Qazzaz, M., Sorge, R.E., Martin, L.J., Zaykin, D.V., Smith, S.B., Freitas, K., Austin, J.-S., Dai, F., Zhang, J., Marcovitz, J., Tuttle, A.H., Slepian, P.M., Clarke, S., Drenan, R.M., Janes, J., Al Sharari, S., Segall, S.K., Aasvang, E.K., Lai, W., Bittner, R., Richards, C.I., Slade, G.D., Kehlet, H., Walker, J., Maskos, U., Changeux, J.-P., Devor, M., Maixner, W., Diatchenko, L., Belfer, I., Dougherty, D.A., Su, A.I., Lummis, S.C.R., Damaj, M.I., Lester, H.A., Patapoutian, A., and Mogil, J.S.  The nicotinic a6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.  Sci. Transl. Med., 7:287ra72, 2015.
  • Samoshkin, A., Convertino, M., Viet, C.T., Wieskopf, J.S., Marcovitz, J., Patel, P., Stone, L., Maixner, W., Mogil, J.S., Schmidt, B.L., Dokholyan, N.V., and Diatchenko, L.  Structural and functional interaction between six transmembrane μ-opioid receptor isoform and β2-adrenoceptors.  Sci. Rep., 5:18198, 2015.
  • Daou, I., Beaudry, H., Ase, A.R., Wieskopf, J.S., Ribeiro-da-Silva, A., Mogil, J.S., and Seguela, P.  Optogenetic silencing of Nav1.8-positive afferents alleviates inflammatory and neuropathic pain.  eNeuro, 3: e0140-15.2016, 2016.
Graduate Student

Currently a psychiatry resident at University of Toronto.

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Department of Psychology 
McGill University 
1205 Dr. Penfield Avenue, Rm. N7/42
Montreal, QC  H3A 1B1

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