Roger B. Fillingim, Ph.D. (Florida State University)



Roger Fillingim is likely the world's foremost authority on sex differences in pain sensitivity in humans.  Roger and Jeff have collaborated on a number of major translational genetics stories, especially those involving sex differences. Roger is the Director of the University of Florida Pain Research and Intervention Center of Excellence.


  • Mogil, J.S., Wilson, S.G., Chesler, E.J., Rankin, A.J., Nemmani, K.V.S., Lariviere, W.R., Groce, M.K., Wallace, M.R., Kaplan, L., Staud, R., Ness, T.J., Glover, T.L., Stankova, M., Mayorov, A., Hruby, V.J., Grisel, J.E., and Fillingim, R.B.  The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans.  Proc. Natl. Acad. Sci. USA, 100:4867-4872, 2003.
  • Fillingim, R.B., Kaplan, L., Staud, R., Ness, T.J., Glover, T.L., Campbell, C.M., Mogil, J.S., and Wallace, M.R.  The A118G single nucleotide polymorphism of the m-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans.  J. Pain, 6:159-167, 2005.
  • Mogil, J.S., Ritchie, J., Smith, S.B., Strasburg, K., Kaplan, L., Wallace, M.R., Romberg, R.R., Bijl, H., Sarton, E.Y., Fillingim, R.B., and Dahan, A.  Melanocortin-1 receptor gene variants affect pain and m-opioid analgesia in mice and humans.  J. Med. Genet., 42:583?587, 2005.
  • Greenspan, J.D., Craft, R.M., LeResche, L., Arendt-Nielsen, L., Berkley, K.J., Fillingim, R.B., Gold, M.S., Holdcroft, A., Lautenbacher, S., Mayer, E.A., Mogil, J.S., Murphy, A.Z., and Traub, R.J., the Consensus Working Group of the Sex, Gender, and Pain SIG of the IASP.  Studying sex and gender differences in pain and analgesia: a consensus report.  Pain, 132:S26-S45, 2007. 
  • Mogil, J.S., Sorge, R.E., LaCroix-Fralish, M.L., Smith, S.B., Fortin, A., Sotocinal, S.G., Ritchie, J., Austin, J.-S., Schorscher-Petcu, A., Melmed, K., Czerminski, J., Bittong, R.A., Mokris, J.B., Neubert, J.K., Campbell, C.M., Edwards, R.R., Campbell, J.N., Crawley, J.N., Lariviere, W.R., Wallace, M.R., Sternberg, W.F., Balaban, C.D., Belfer, I., and Fillingim, R.B.  Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.  Nat. Neurosci., 14:1569-1573, 2011.
  • Hastie, B.A., Riley, J.L., III, Kaplan, L., Herrera, D.G., Campbell, C.M., Virtusio, K., Mogil, J.S., Wallace, M.R., and Fillingim, R.B.  Ethnicity interacts with the OPRM1 gene in experimental pain sensitivity.  Pain, 153:1610-1619, 2012.
  • Parisien, M., Khoury, S., Chabot-Dore, A.-J., Sotocinal, S.G., Slade, G.D., Smith, S.B., Fillingim, R.B., Ohrbach, R., Greenspan, J.D., Maixner, W., Mogil, J.S., Belfer, I., and Diatchenko, L. Effect of human genetic variability on gene transcription in dorsal root ganglia and association with pain phenotypes. Cell Rep., 19:1940-1952, 2017.
  • Martin, L.J., Smith, S.B., Khoutorsky, A., Magnussen, C.A., Samoshkin, A., Sorge, R.E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khong, T.M., Mir, E., Gibson, D.G., Wieskopf, J.S., Sotocinal, S.G., Austin, J.-S., Meloto, C.B., Gitt, J.H., Gkogkas, C., Sonenberg, N., Greenspan, J., Fillingim, R.B., Ohrbach, R., Slade, G.D., Knott, C., Dubner, R., Nackley, A.G., Ribeiro-da-Silva, A., Neely, G.G., Maixner, W., Zaykin, D.V., Mogil, J.S., and Diatchenko, L.  Epiregulin and EGFR interactions are involved in pain processing.  J. Clin. Invest., 127:3353-3363, 2017.
  • Boerner, K.E., Chambers, C.T., Gahagan, J., Keogh, E., Fillingim, R.B., and Mogil, J.S.  The conceptual complexity of gender and its relevance to pain.  Pain, in press.

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