Judith E. Grisel, Ph.D. (Oregon Health Sciences University)

Postdoc buddies


An alcohol genetics researcher in the laboratory of Dr. John Crabbe at OHSU, Judy and Jeff nonetheless collaborated on a number of each other's experiments.  An especially fruitful collaboration concerned the then novel pain-relevant peptide, orphanin FQ/nociceptin, work performed with David Grandy at OHSU.  The Grisel laboratory at Bucknell studies the etiology of alcohol and drug abuse, especially with respect to opioid mechanisms.


  • Mogil, J.S., Grisel, J.E., Reinscheid, R.K., Civelli, O., Belknap, J.K., and Grandy, D.K. Orphanin FQ is a functional anti-opioid peptide. Neuroscience, 75:333-337, 1996.
  • Mogil, J.S., Grisel, J.E., Zhang, G., Belknap, J.K., and Grandy, D.K. Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ.Neurosci. Lett., 214:131-134, 1996.
  • Grisel, J.E., Mogil, J.S., Belknap, J.K., and Grandy, D.K. Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. Neuroreport, 7:2125-2129, 1996.
  • Tian, J.-H., Xu, W., Fang, Y., Mogil, J.S., Grisel, J.E., Grandy, D.K., and Han, J.-S. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. Br. J. Pharmacol., 120:676-680, 1997.
  • Tian, J.-H., Xu, W., Fang, Y., Grisel, J.E., Mogil, J.S., Grandy, D.K., and Han, J.-S. Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia.Neuroreport, 8:497-500, 1997.
  • Mogil, J.S. and Grisel, J.E. Transgenic studies of pain. Pain, 77: 107-128, 1998.Grisel, J.E., Farrier, D.E., Wilson, S.G., and Mogil, J.S. [Phe1Y(CH2-NH)Gly2] nociceptin-(1-13)-NH2 acts as an agonist of the orphanin FQ/nociceptin receptor in vivo. Eur. J. Pharmacol., 357:1-3, 1998.
  • Mogil, J.S., and Grisel, J.E. Toward a functional characterization of orphanin FQ/ nociceptin: parametric and organismic considerations. Eur. J. Pain, 2:278-280, 1998.
  • Grisel, J.E., Mogil, J.S., Grahame, N.J., Rubinstein, M., Belknap, J.K., Crabbe, J.C., and Low, M. Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression. Brain Res., 835:62-67, 1999.
  • Grisel, J.E. and Mogil, J.S. Effects of supraspinal orphanin FQ/nociceptin. Peptides, 21:1037- 1045, 2000.
  • Mogil, J.S., Grisel, J.E., Bales, J.R., Hayward, M.D., Rubinstein, M., Belknap, J.K., and Low, M. Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience, 101:709-717, 2000.
  • Mogil, J.S., Wilson, S.G., Chesler, E.J., Rankin, A.J., Nemmani, K.V.S., Lariviere, W.R., Groce, M.K., Wallace, M.R., Kaplan, L., Staud, R., Ness, T.J., Glover, T.L., Stankova, M., Mayorov, A., Hruby, V.J., Grisel, J.E., and Fillingim, R.B. The melanocortin-1 receptor gene mediates female- specific mechanisms of analgesia in mice and humans. Proc. Natl. Acad. Sci. USA, 100:4867- 4872, 2003.
  • Nemmani, K.V.S., Grisel, J.E., Stowe, J.R., Smith-Carliss, R., and Mogil, J.S. Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. Pain, 109:274-283, 2004.

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