Robert E. Sorge, Ph.D. (Concordia University)

Postdoctoral Fellow
2009-2012

Translational Regulation and Pain

Currently Assistant Professor, Dept. of Psychology, University of Alabama at Birmingham

https://www.uab.edu/cas/psychology/people/primary-faculty-directory/robert-sorge

 
  • Langford, D.J., Bailey, A.L., Chanda, M.L., Clarke, S.E., Drummond, T.E., Echols, S., Glick, S., Ingrao, J., Klassen-Ross, T., LaCroix-Fralish, M.L., Matsumiya, L., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wong, D., van den Maagdenberg, A.M.J.M., Ferrari, M.D., Craig, K.D., and Mogil, J.S. Coding of facial expressions of pain in the laboratory mouse. Nat. Meth., 7:447-449, 2010.
  • Schorscher-Petcu, A., Sotocinal, S.G., Ciura, S., Dupre, A., Ritchie, J.,Sorge, R.E., Crawley, J.N., Hu, S.-B., Nishimori, K., Young, L.J., Tribollet, E., Quirion, R., and Mogil, J.S. Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse. J. Neurosci., 30:8274-8284, 2010. 
  • Sotocinal, S.G., Sorge, R.E., Zaloum, A., Tuttle, A.H., Martin, L.J., Wieskopf, J.S., Mapplebeck, J.C.S., Wei, P., Zhan, S., Zhang, S., McDougall, J.J., King, O.D., and Mogil, J.S. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol. Pain, 7:55, 2011.
  • Matsumiya, L.C., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wieskopf, J.S., Zaloum, A., King, O.D., and Mogil, J.S. Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. J. Am. Assoc. Lab. Anim. Sci., 51:42-49, 2012.
  • Mogil, J.S., Sorge, R.E., LaCroix-Fralish, M.L., Smith, S.B., Fortin, A., Sotocinal, S.G., Ritchie, J.R., Austin, J.-S., Schorscher-Petcu, A., Melmed, K., Czerminski, J., Bittong, R.A., Mokris, J.B., Neubert, J.K., Campbell, C.M., Edwards, R.R., Campbell, J.N., Crawley, J.N., Lariviere, W.R., Wallace, M.R., Sternberg, W.F., Balaban, C.D., Belfer, I., and Fillingim, R.B. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat. Neurosci., 14:1569-1573, 2011.
  • Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Sotocinal, S.G., Austin, J.-S., Ritchie, J., Chanda, M.L., Graham, A.C., Topham, L., Beggs, S., Salter, M.W., and Mogil, J.S. Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice. J. Neurosci., 31:15450-15454, 2011.
  • Sorge, R.E., Trang, T., Dorfman, R., Smith, S.B., Beggs, S., Ritchie, J., Austin, J.-S., Zaykin, D.V., Vander Meulen, H., Costigan, M., Herbert, T.A., Yarkoni-Abitbul, M., Tichauer, D., Livneh, J., Gershon, E., Zheng, M., Tan, K., John, S.L., Slade, G.D., Jordan, J., Woolf, C.J., Peltz, G., Maixner, W., Diatchenko, L., Seltzer, Z., Salter, M.W., and Mogil, J.S. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat. Med., 18:595-599, 2012.
  • Malfait, A.M., Seymour, A.B., Gao, F., Tortorella, M.D., Hellio Le Graverand-Gastineau, M.P., Wood, L.S., Doherty, M., Doherty, S., Zhang, W., Arden, N.K., Vaughn, F.L., Leaverton, P.E., Spector, T.D., Hart, D.J., Maciewicz, R.A., Muir, K.R., Das, R., Sorge, R.E., Sotocinal, S.G., Schorscher-Petcu, A., Valdes, A.M., and Mogil, J.S. A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype. Ann. Rheum. Dis., 71:1042-1048, 2012.
  • Tsao, D., Wieskopf, J.S., Rashid, N., Sorge, R.E., Segall, S.K., Mogil, J.S., Maixner, W., Dokholyan, N.V., and Diatchenko, LSerotonin-induced hypersensitivity via inhibition of catechol-O-methyltransferase activity. Mol. Pain, 8:25, 2012. 
  • Khoutorsky, A., Yanagiya, A., Gkogkas, C., Fabian, M.R., Prager-Khoutorsky, M., Cao, R., Gamache, K., Bouthiette, F., Parsyan, A.,Sorge, R.E., Mogil, J.S., Nader, K., Lacaille, J.-C., and Sonenberg, N. Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Neuron, 78:298-311, 2013.
  • Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Khoutorsky, A., Sotocinal, S.G., Austin, J.-S., Melmed, K., Labialle, S., Schmidt, J.V., Wood, J.N., Naumova, A.K., and Mogil, J.S. The yin and yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene. Genes Brain Behav., 12:405-413, 2013.
  • Melemedjian, O.K., Khoutorsky, A., Sorge, R.E., Yan, J., Asiedu, M.N., Valdez, A., Ghosh, S., Dussor, G., Mogil, J.S., Sonenberg, N., and Price, T.J.  mTORC1 inhibition induces pain via IRS1-dependent feedback activation of ERK.  Pain, 154:1080-1091, 2013.
  • Sorge, R.E., Martin, L.J., Isbester, K.A., Sotocinal, S.G., Rosen, S., Tuttle, A.H., Wieskopf, J.S., Acland, E.L., Dokova, A., Kadoura, B., Leger, P., Mapplebeck, J.C.S., McPhail, M., Delaney, A., Wigerblad, G., Schumann, A.P., Quinn, T., Frasnelli, J., Svensson, C.I., Sternberg, W.F., and Mogil, J.S.  Olfactory exposure to males, including human males, stresses rodents.  Nat. Meth., 11:629-632, 2014.
  • Cahill, L.S., Laliberte, C.L., Liu, X.J., Bishop, J., Nieman, B.J., Mogil, J.S., Sorge, R.E., Jones, C.D., Salter, M.W., and Henkelman, R.M.  Quantifying blood-spinal cord barrier permeability after peripheral nerve injury in the living mouse. Mol. Pain, 10:60, 2014.
  • Wieskopf, J.S., Mathur, J., Limapichat, W., Post, M.R., Al-Qazzaz, M., Sorge, R.E., Martin, L.J., Zaykin, D.V., Smith, S.B., Freitas, K., Austin, J.-S., Dai, F., Zhang, J., Marcovitz, J., Tuttle, A.H., Slepian, P.M., Clarke, S., Drenan, R.M., Janes, J., Al Sharari, S., Segall, S.K., Aasvang, E.K., Lai, W., Bittner, R., Richards, C.I., Slade, G.D., Kehlet, H., Walker, J., Maskos, U., Changeux, J.-P., Devor, M., Maixner, W., Diatchenko, L., Belfer, I., Dougherty, D.A., Su, A.I., Lummis, S.C.R., Damaj, M.I., Lester, H.A., Patapoutian, A., and Mogil, J.S.  The nicotinic a6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.  Sci. Transl. Med., 7:287ra72, 2015.
  • Sorge, R.E., Mapplebeck, J.C.S., Rosen, S., Beggs, S., Taves, S., Alexander, J.K., Martin, L.J., Austin, J.-S., Sotocinal, S.G., Chen, D., Yang, M., Shi, X.Q., Huang, H., Pillon, N.J., Bilan, P.J., Tu, Y., Klip, A., Ji, R.-R., Zhang, J., Salter, M.W. and Mogil, J.S.  Different immune cells mediate mechanical pain hypersensitivity in male and female mice.  Nat. Neurosci., 18:1081-1083, 2015.
  • Khoutorsky, A.*, Bonin, R.P.*, Sorge, R.E.*, Gkogkas, C., Pawlowski, S.A., Jafarnejad, S.M., Pitcher, M.H., Alain, T., Perez-Sanchez, J., Salter, E.W., Martin, L.J., Ribeiro-da-Silva, A., De Koninck, Y., Cervero, F., Mogil, J.S., and Sonenberg, N.  Translational control of nociception via 4E-binding protein 1.  eLife 4:e12002, 2015.  (*co-first authors) 
  • Khoutorsky, A., Sorge, R.E., Prager-Khoutorsky, M., Pawlowski, S.A., Longo, G., Jafarnejad, S.M., Tahmesebi, S., Martin, L.J., Pitcher, M.H., Gkogkas, C.G., Sharif-Naeini, R., Ribeiro-da-Silva, A., Bourque, C.W., Cervero, F., Mogil, J.S., and Sonenberg, N. eIF2a phosphorylation controls thermal nociception.  Proc. Natl. Acad. Sci., U.S.A., 113:11949-11854, 2016.
  • Martin, L.J., Smith, S.B., Khoutorsky, A., Magnussen, C.A., Samoshkin, A., Sorge, R.E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khong, T.M., Mir, E., Gibson, D.G., Wieskopf, J.S., Sotocinal, S.G., Austin, J.-S., Meloto, C.B., Gitt, J.H., Gkogkas, C., Sonenberg, N., Greenspan, J., Fillingim, R.B., Ohrbach, R., Slade, G.D., Knott, C., Dubner, R., Nackley, A.G., Ribeiro-da-Silva, A., Neely, G.G., Maixner, W., Zaykin, D.V., Mogil, J.S., and Diatchenko, L.  Epiregulin and EGFR interactions are involved in pain processing.  J. Clin. Invest., 127:3353-3363, 2017. 
Postdoctoral Fellow
Position:

Currently Assistant Professor, Dept. of Psychology, University of Alabama at Birmingham

https://www.uab.edu/cas/psychology/people/primary-faculty-directory/robert-sorge



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Department of Psychology 
McGill University 
1205 Dr. Penfield Avenue, Rm. N7/42
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jeffrey.mogil@mcgill.ca
Tel.  514.398.6085
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