Michael L. Lacroix-Fralish, Ph.D. (Dartmouth)

Postdoctoral Fellow
2007-2009

Pain Genetics

Currently a Senior Staff Scientist at Regeneron Pharmaceuticals, Inc.

michael.fralish@regeneron.com

 
  • LaCroix-Fralish, M.L., Rutkowski, M.D., Weinstein, J.N., Mogil, J.S., and DeLeo, J.A.  The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex.  Spine 30:1821-1827, 2005.
  • LaCroix-Fralish, M.L., Ledoux, J.B., and Mogil, J.S.  The Pain Genes Database: an interactive browser of pain-related transgenic knockout studies. Pain131:3.e1-3e4, 2007.
  • Rice, A.S.C., Cimino-Brown, D., Eisenach, J.C., Kontinen, V.K., LaCroix-Fralish, M.L., Machin, I., Mogil, J.S., and Stohr, T.  Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards.  Pain 139:241-245, 2008.
  • LaCroix-Fralish, M.L. and Mogil, J.S.  Progress in genetic studies of pain and analgesia.  Annu. Rev. Pharmacol. 49:97-121, 2009.
  • LaCroix-Fralish, M.L., Mo, G., Smith, S.B., Sotocinal, S.G., Ritchie, J., Austin, J.-S., Melmed, K., Schorscher-Petcu, A., Laferriere, A., Lee, T.H., Romanovsky, D., Liao, G., Behlke, M.A., Clark, J.D., Peltz, G., Seguela, P., Dobretsov, M., and Mogil, J.S.  The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.  Pain, 144:294-302, 2009.
  • Langford, D.J., Bailey, A.L., Chanda, M.L., Clarke, S.E., Drummond, T.E., Echols, S., Glick, S., Ingrao, J., Klassen-Ross, T., LaCroix-Fralish, M.L., Matsumiya, L., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wong, D., van den Maagdenberg, A.M.J.M., Ferrari, M.D., Craig, K.D., and Mogil, J.S. Coding of facial expressions of pain in the laboratory mouse.  Nat. Meth., 7:447-449, 2010.
  • Lacroix-Fralish, M.L., Austin, J.-S., Zhang, F.Y., Levitin, D.J., and Mogil, J.S.  Patterns of pain: meta-analysis of microarray studies of pain.  Pain, 152:1888-1898, 2011.
  • Mogil, J.S., Sorge, R.E., LaCroix-Fralish, M.L., Smith, S.B., Fortin, A., Sotocinal, S.G., Ritchie, J.R., Austin, J.-S., Schorscher-Petcu, A., Melmed, K., Czerminski, J., Bittong, R.A., Mokris, J.B., Neubert, J.K., Campbell, C.M., Edwards, R.R., Campbell, J.N., Crawley, J.N., Lariviere, W.R., Wallace, M.R., Sternberg, W.F., Balaban, C.D., Belfer, I., and Fillingim, R.B. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat. Neurosci., 14:1569-1573, 2011.
  • Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Sotocinal, S.G., Austin, J.-S., Ritchie, J., Chanda, M.L., Graham, A.C., Topham, L., Beggs, S., Salter, M.W., and Mogil, J.S.  Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice.  J. Neurosci., 31:15450-15454, 2011.
  • Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Khoutorsky, A., Sotocinal, S.G., Austin, J.-S., Melmed, K., Labialle, S., Schmidt, J.V., Wood, J.N., Naumova, A.K., and Mogil, J.S. The yin and yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene. Genes, Brain and Behavior, 12:405-413, 2013.
Postdoctoral Fellow
Position:

Currently a Senior Staff Scientist at Regeneron Pharmaceuticals, Inc.

michael.fralish@regeneron.com



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