John K. Belknap, Ph.D. (deceased) (Oregon Health Sciences University)

Postdoctoral Advisor


1993-1996
 

Everything Jeff knows about genetics he learned from John Belknap.  Although primarily an alcohol researcher, John performed the first real pain-relevant QTL mapping study, of morphine analgesia, in 1992. John Belknap died in 2017.  An obituary Jeff was invited to write for Genes, Brain and Behavior can be found here:  https://www.ncbi.nlm.nih.gov/pubmed/28371290.

Co-Publications:

  • Marek, P., Mogil, J.S., Belknap, J.K., Sadowski, B., and Liebeskind, J.C. Levorphanol and swim stress-induced analgesia in selectively bred mice: evidence for genetic commonalties. Brain Res., 608:353-357, 1993.
  • Mogil, J.S., Marek, P., O'Toole, L.A., Helms, M.L., Sadowski, B., Liebeskind, J.C., and Belknap, J.K. Mu-opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia. Brain Res., 653:16-22, 1994.
  • Belknap, J.K., Mogil, J.S., Helms, M.L., O'Toole, L.A., Richards, S.P., and Bergeson, S.E. Genetic mapping to proximal Chromosome 10 of a locus influencing morphine- induced analgesia in C57BL/6 and DBA/2 mouse strains.Life Sci., 57:PL117-124, 1995.
  • Mogil, J.S., Kest, B., Sadowski, B., and Belknap, J.K. Differential genetic mediation of sensitivity to morphine in genetic models of opiate sensitivity: influence of nociceptive assay. J. Pharmacol. Exp. Ther., 276:532-544, 1996.
  • Mogil, J.S., Sternberg, W.F., Marek, P., Sadowski, B., Belknap, J.K. and Liebeskind, J.C. The genetics of pain and pain inhibition. Proc. Natl. Acad. Sci., USA, 93:3048-3055, 1996.
  • Mogil, J.S., Grisel, J.E., Reinscheid, R.K., Civelli, O., Belknap, J.K., and Grandy, D.K. Orphanin FQ is a functional anti-opioid peptide. Neuroscience, 75:333-337, 1996.
  • Mogil, J.S., Grisel, J.E., Zhang, G., Belknap, J.K., and Grandy, D.K. Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ.Neurosci. Lett., 214:131-134, 1996.
  • Grisel, J.E., Mogil, J.S., Belknap, J.K., and Grandy, D.K. Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. Neuroreport, 7:2125-2129, 1996.
  • Mogil, J.S. and Belknap, J.K. Sex and genotype determine the selective activation of neurochemically-distinct forms of swim stress-induced analgesia.Pharmacol. Biochem. Behav., 56:61-66, 1997.
  • Mogil, J.S., Richards, S.P., O'Toole, L.A., Helms, M.L., Mitchell, S.R., andBelknap, J.K. Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by delta2-opioid receptors. Pain, 70:267-277, 1997.
  • Mogil, J.S., Richards, S.P., O'Toole, L.A., Mitchell, S.R., Helms, M.L., Kest, B., and Belknap, J.K. Identification of sex-specific quantitative trait loci mediating non-opioid swim stress-induced analgesia in female mice. J. Neurosci., 17:7995-8002, 1997.
  • Kest, B., McLemore, G.L., Sadowski, B., Mogil, J.S., Belknap, J.K., and Inturrisi, C.E. Acute morphine dependence in mice selectively-bred for high and low analgesia. Neurosci. Lett., 256:120-122, 1998.
  • Kest, B., Jenab, S., Brodsky, M., Sadowski, B., Belknap, J.K., Mogil, J.S., and Inturrisi, C.E. Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia. Brain Res., 816:381-389, 1999.
  • Mogil, J.S., Wilson, S.G., Bon, K., Lee, S.E., Chung, K., Raber, P., Pieper, J.O., Hain, H.S., Belknap, J.K., Hubert, L., Elmer, G.I., Chung, J.M., and Devor, M. Heritability of nociception. I. Responses of eleven inbred mouse strains on twelve measures of nociception. Pain, 80:67-82, 1999.
  • Mogil, J.S., Wilson, S.G., Bon, K., Lee, S.E., Chung, K., Raber, P., Pieper, J.O., Hain, H.S., Belknap, J.K., Hubert, L., Elmer, G.I., Chung, J.M., and Devor, M. Heritability of nociception. II. 'Types' of nociception revealed by genetic correlation analysis. Pain, 80:83-93, 1999.
  • Grisel, J.E., Mogil, J.S., Grahame, N.J., Rubinstein, M., Belknap, J.K., Crabbe, J.C., and Low, M. Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression. Brain Res., 835:62-67, 1999.
  • Hain, H., Belknap, J.K., and Mogil, J.S. Pharmacogenetic evidence for the involvement of 5? hydroxytryptamine (serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity. J. Pharmacol. Exp. Ther., 291:444-449, 1999.
  • Mogil, J.S., Grisel, J.E., Bales, J.R., Hayward, M.D., Rubinstein, M., Belknap, J.K., and Low, M. Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience, 101:709-717, 2000.
  • Bergeson, S.E., Helms, M.L., O'Toole, L.A., Jarvis, M.W., Hain, H.S., Mogil, J.S., and Belknap, J.K. Quantitative trait loci influencing morphine antinociception in four mapping populations. Mamm. Genome, 12:546-553, 2001.
  • Wilson, S.G., Chesler, E.J., Hain, H., Rankin, A.J., Schwarz, J.Z., Call, S.B., Murray, M.R., West, E.E., Teuscher, C., Rodriguez-Zas, S., Belknap, J.K., and Mogil, J.S. Identification of quantitative trait loci for chemical/inflammatory nociception in mice. Pain, 96:385-391, 2002.
  • The Complex Trait Consortium. The nature and identification of quantitative trait loci: a community's view. Nature Genet. Rev., 4:911-916, 2003.


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Department of Psychology 
McGill University 
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