Original Papers

*20+ citations, **50+ citations, ***100+ citations

 

  • Khoutorksy, A., Sorge, R.E., Prager-Khoutorksy, M., Pawlowski, S.A., Longo, G., Jafarnejad, S.M., Tahmasebi, S., Martin, L.J., Pitcher, M.H., Gkogkas, C.G., Sharif-Naeini, R., Ribeiro-da-Silva, A., Bourque, C.W., Cervero, F., Mogil, J.S.*, and Sonenberg, N.* EiF2alpha phosphorylation controls thermal nociception.  Proceedings of the National Academy of Sciences, U.S.A., 113:11949-11954, 2016.  (*co-senior authors)
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  • Ultsch, A., Kringel, D., Kalso, E., Mogil, J.S., and Lotsch, J. A data science approach to candidate gene selection of pain regarded as a process of learning and neural plasticity.  Pain, 157:2747-2757, 2016.
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  • Kikusui, T., Ishio, Y., Nagasawa, M., Mogil, J.S., and Mogi, K. Early weaning impairs a social contagion of pain-related stretching behavior in mice.  Developmental Psychobiology, 58:1101-1107, 2016.
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  • Young, E., Bryant, C., Lee, S., Nair, H., Dreher, K., Zhang, X., Palmer, A., Chung, J.M., Mogil, J.S., Chesler, E., and Lariviere, W.  Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test.  Genes, Brain and Behavior, 15:604-615, 2016.
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  • Kahle, K.T., Schmouth, J.F., Lavastre, V., Latremoliere, A., Zhang, J., Andrews, N., Omura, T., Laganiere, J., Rochefort, D., Hince, P., Castonguay, G., Gaudet, R., Mapplebeck, J.C., Sotocinal, S.G., Duan, J., Ward, C., Khanna, A.R., Mogil, J.S., Dion, P.A., Woolf, C.J., Inquimbert, P., and Rouleau, G.A.  Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.  Science Signaling, 9:ra32, 2016. 
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  • Daou, I., Beaudry, H., Ase, A.R., Wieskopf, J.S., Ribeiro-da-Silva, A., Mogil, J.S., and Seguela, P.  Optogenetic silencing of Nav1.8-positive afferents alleviates inflammatory and neuropathic pain.  eNeuro, 3:e0140-15.2016, 2016.
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  • Khoutorsky, A., Bonin, R.P., Sorge, R.E., Gkogkas, C., Pawlowski, S.A., Jafarnejad, S.M., Pitcher, M.H., Alain, T., Perez-Sanchez, J., Salter, E.W., Martin, L.J., Ribeiro-da-Silva, A., De Koninck, Y., Cervero, F., Mogil, J.S.*, and Sonenberg, N.* Translational control of nociception via 4E-binding protein 1.  eLife, 4:e12002, 2015.  (*co-corresponding authors)
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  • Samoshkin, A., Convertino, M., Viet, C.T., Wieskopf, J.S., Marcovitz, J., Patel, P., Stone, L., Maixner, W., Mogil, J.S., Schmidt, B.L., Dokholyan, N.V., and Diatchenko, L.  Structural and functional interaction between six transmembrane μ-opioid receptor isoform and β2-adrenoceptors.  Science Reports, 5:18198, 2015.
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  • Martin, L.J., Piltonen, M.H., Gauthier, J., Convertino, M., Acland, E.L., Dokholyan, N.V., Mogil, J.S., Diatchenko, L., and Maixner, W.  Differences in the antinociceptive effects and binding properties of propranolol and bupranolol enantiomers. Journal of Pain, 16:1321-1333, 2015.
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  • Tuttle, A.H., Tohyama, S., Ramsay, T., Kimmelman, J., Schweinhardt, P., Bennett, G.J., and Mogil, J.S.  Increasing placebo responses over time in U.S. clinical trials of neuropathic pain.  Pain, 156:2616-2626, 2015.
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  • Segall, S.K., Shabalina, S.A., Meloto, C.B., Wen, X., Cunningham, D., Tarantino, L.M., Wiltshire, T., Gauthier, J., Tohyama, S., Martin, L.J., Mogil, J.S., and Diatchenko, L.  Molecular genetic mechanisms of allelic specific regulation of murine Comt expression.  Pain, 156:1965-1977, 2015.
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  • Sorge, R.E., Mapplebeck, J.C.S., Rosen, S., Beggs, S., Taves, S., Alexander, J.K., Martin, L.J., Austin, J.-S., Sotocinal, S.G., Chen, D., Yang, M., Shi, X.Q., Huang, H., Pillon, N.J., Bilan, P.J., Tu, Y., Klip, A., Ji, R.-R., Zhang, J., Salter, M.W. and Mogil, J.S.  Different immune cells mediate mechanical pain hypersensitivity in male and female mice.  Nature Neuroscience, 18:1081-1083, 2015.**
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  • Wieskopf, J.S., Mathur, J., Limapichat, W., Post, M.R., Al-Qazzaz, M., Sorge, R.E., Martin, L.J., Zaykin, D.V., Smith, S.B., Freitas, K., Austin, J.-S., Dai, F., Zhang, J., Marcovitz, J., Tuttle, A.H., Slepian, P.M., Clarke, S., Drenan, R.M., Janes, J., Al Sharari, S., Segall, S.K., Aasvang, E.K., Lai, W., Bittner, R., Richards, C.I., Slade, G.D., Kehlet, H., Walker, J., Maskos, U., Changeux, J.-P., Devor, M., Maixner, W., Diatchenko, L., Belfer, I., Dougherty, D.A., Su, A.I., Lummis, S.C.R., Damaj, M.I., Lester, H.A., Patapoutian, A., and Mogil, J.S.  The nicotinic a6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.  Science Translational Medicine, 7:287ra72, 2015.
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  • Szabo, N.E., da Silva, R.V., Sotocinal, S.G., Zeilhofer, H.U., Mogil, J.S., and Kania, A.  Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity and nociception.  Journal of Neuroscience, 35:5233-5246, 2015.
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  • Martin, L.J., Hathaway, G., Isbester, K., Mirali, S., Acland, E.L., Niederstrasser, N., Slepian, P.M., Trost, Z., Bartz, J.A., Sapolsky, R.M., Sternberg, W.F., Levitin, D.J., and Mogi, J.S.  Reducing social stress elicits emotional contagion of pain in mouse and human strangers. Current Biology, 25:326-332, 2015.
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  • Cahill, L.S., Laliberte, C.L., Liu, X.J., Bishop, J., Nieman, B.J., Mogil, J.S., Sorge, R.E., Jones, C.D., Salter, M.W., and Henkelman, R.M.  Quantifying blood-spinal cord barrier permeability after peripheral nerve injury in the living mouse. Molecular Pain, 10:60, 2014.
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  • Wieskopf, J.S., Pan, Y.-X., Marcovitz, J., Tuttle, A.H., Majumdar, S., Pidakala, J., Pasternak, G.W., and Mogil, J.S. Broad spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene. Pain, 155:2063-2070, 2014.
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  • Tang, S., Ding, Y., Sibille, E. Mogil, J.S., Lariviere, W.R., and Tseng, G.C.  Imputation of truncated p-values for meta-analysis methods and its genomic application.  Annals of Applied Statistics, 8:2150-2174, 2014.
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  • Kimmelman, J., Mogil, J.S., Dirnagl, U.  Distinguishing between exploratory and confirmatory preclinical research will improve translation.  PLoS Biology, 12:e1001863, 2014.*
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  • Sorge, R.E., Martin, L.J., Isbester, K.A., Sotocinal, S.G., Rosen, S., Tuttle, A.H., Wieskopf, J.S., Acland, E.L., Dokova, A., Kadoura, B., Leger, P., Mapplebeck, J.C.S., McPhail, M., Delaney, A., Wigerblad, G., Schumann, A.P., Quinn, T., Frasnelli, J., Svensson, C.I., Sternberg, W.F., and Mogil, J.S.  Olfactory exposure to males, including human males, stresses rodents.  Nature Methods, 11:629-632, 2014.***
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  • Farmer, M.A., Leja, A., Foxen-Craft, E., Chan, L., MacIntyre, L.C., Niaki, T., Chen, M., Mapplebeck, J.C.S., Tabry, V., Topham, L., Sukosd, M., Binik, Y.M., Pfaus, J.G., and Mogil, J.S.  Pain reduces sexual motivation in female but not male mice.  Journal of Neuroscience, 34:5747-5753, 2014.
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  • Kristiansen, F.L., Olesen, A.E., Brock, C., Gazerani, P., Petrini, L., Mogil, J.S., and Drewes, A.M.  The role of pain catastrophizing in experimental pain perception.  Pain Practitioner, 14:E136-145, 2014.
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  • Daou, I., Tuttle, A.H., Long, G., Wieskopf, J.S., Bonin, R., Ase, A., Wood, J.N., De Koninck, Y., Ribeiro-da-Silva, A., Mogil, J.S., and Seguela, P.  Remote optogenetic activation and sensitization of pain pathways in freely moving mice.  Journal of Neuroscience, 33:18631-18640, 2013.*
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  • Corder, G., Doolen, S., Donahue, R.R., Winter, M.K., Jutras, B.L., He, Y., Hu, X., Wieskopf, J.S., Mogil, J.S., Storm, D.R., Wang, Z.J., McCarson, K.E., and Taylor, B.K.  Constitutive m-opioid receptor activity leads to long-term endogenous analgesia and dependence.  Science, 341:1394-1399, 2013.
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  • Belfer, I., Segall, S.K., Lariviere, W.R., Smith, S.B., Dai, F., Slade, G.G., Rashid, N.U., Mogil, J.S., Campbell, C.M., Edwards, R.R., Liu, Q., Bair, E., Maixner, W., and Diatchenko, L.  Pain modality- and sex-specific effects of COMT functional variants.  Pain, 154:1368-1376, 2013.* 
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  • Chanda, M.L., Tuttle, A.H., Baran, I., Atlin, C., Guindi, D., Hathaway, G., Israelian, N., Levenstadt, J., Low, D., Macrae, L., O'Shea, L., Silver, A., Zendegui, E., Lenselink, A.M., Spijker, S., Ferrari, M.D., van den Maagdenberg, A.M.J.M., and Mogil, J.S.  Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice.  Pain, 154:1254-1262, 2013.
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  • Lotsch, J., Doehring, A., Mogil, J.S., Arndt, T., Geisslinger, G., and Ultsch, A.  Functional genomics of pain in analgesic drug development and therapy.  Pharmacology & Therapeutics, 139:60-70, 2013.* 
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  • Melemedjian, O.K., Khoutorsky, A., Sorge, R.E., Yan, J., Asiedu, M.N., Valdez, A., Ghosh, S., Dussor, G., Mogil, J.S., Sonenberg, N., and Price, T.J.  mTORC1 inhibition induces pain via IRS1-dependent feedback activation of ERK.  Pain, 154:1080-1091, 2013.*
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  • Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Khoutorsky, A., Sotocinal, S.G., Austin, J.-S., Melmed, K., Labialle, S., Schmidt, J.V., Wood, J.N., Naumova, A.K., and Mogil, J.S.  The yin and yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene.  Genes, Brain and Behavior, 12:405-413, 2013. 
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  • Khoutorsky, A., Yanagiya, A., Gkogkas, C., Fabian, M.R., Prager-Khoutorsky, M., Cao, R., Gamache, K., Bouthiette, F., Parsyan, A., Sorge, R.E., Mogil, J.S., Nader, K., Lacaille, J.-C., and Sonenberg, N.  Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Neuron, 78:298-311, 2013.
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  • Hastie, B.A., Riley, J.L., III, Kaplan, L., Herrera, D.G., Campbell, C.M., Virtusio, KI., Mogil, J.S., Wallace, M.R., and Fillingim, R.B.  Ethnicity interacts with the OPRM1 gene in experimental pain sensitivity.  Pain, 153:1610-1619, 2012.
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  • Tsao, D., Wieskopf, J.S., Rashid, N., Sorge, R.E., Redler, R.L., Segall, S.K., Mogil, J.S., Maixner, W., Dokholyan, N.V., and Diatchenko, L.  Serotonin-induced hypersensitivity via inhibition of catechol-O-methyltransferase.  Molecular Pain, 8:25, 2012.
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  • Malfait, A.M., Seymour, A.B., Gao, F., Tortorella, M.D., Hellio Le Graverand-Gastineau, M.P., Wood, L.S., Doherty, M., Doherty, S., Zhang, W., Arden, N.K., Vaughn, F.L., Leaverton, P.E., Spector, T.D., Hart, D.J., Maciewicz, R.A., Muir, K.R., Das, R., Sorge, R.E., Sotocinal, S.G., Schorscher-Petcu, A., Valdes, A.M., and Mogil, J.S.  A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.  Annals of Rheumatic Disease, 71:1042-1048, 2012.*
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  • Sorge, R.E., Trang, T., Dorfman, R., Smith, S.B., Beggs, S., Ritchie, J., Austin, J.-S., Zaykin, D.V., Vander Meulen, H., Costigan, M., Herbert, T.A., Yarkoni-Abitbul, M., Tichauer, D., Livneh, J., Gershon, E., Zheng, M., Tan, K., John, S.L., Slade, G.D., Jordan, J., Woolf, C.J., Peltz, G., Maixner, W., Diatchenko, L., Seltzer, Z., Salter, M.W., and Mogil, J.S.  Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.  Nature Medicine, 18:595-599, 2012.***
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  • Shekerabi, M., Moldrich, R., Rasheed, S., Salin-Cantegrel, A., Laganiere, J., Rochesfort, D., Hince, P., Huot, K., Gaudet, R., Kurniawan, N., Sotocinal, S.G., Ritchie, J., Dion, P., Mogil, J.S., Richards, L., and Rouleau, G.  Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum. Journal of Neuroscience, 32:3865-3876, 2012.
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  • Matsumiya, L.C., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wieskopf, J.S., Zaloum, A., King, O.D., and Mogil, J.S. Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. Journal of the American Association of Laboratory Animal Science, 51:42-49, 2012.*
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  • Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Sotocinal, S.G., Austin, J.-S., Ritchie, J., Chanda, M.L., Graham, A.C., Topham, L., Beggs, S., Salter, M.W., and Mogil, J.S.  Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice.  Journal of Neuroscience, 43:15450-15454, 2011.**
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  • Mogil, J.S., Sorge, R.E., LaCroix-Fralish, M.L., Smith, S.B., Fortin, A., Sotocinal, S.G., Ritchie, J.R., Austin, J.-S., Schorscher-Petcu, A., Melmed, K., Czerminski, J., Bittong, R.A., Mokris, J.B., Neubert, J.K., Campbell, C.M., Edwards, R.R., Campbell, J.N., Crawley, J.N., Lariviere, W.R., Wallace, M.R., Sternberg, W.F., Balaban, C.D., Belfer, I., and Fillingim, R.B.  Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.  Nature Neuroscience, 14:1569-1573, 2011. 
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  • Farmer, M.A., Taylor, A.M., Bailey, A.L., Tuttle, A.H., MacIntyre, L.C., Milagrosa, Z.E., Crissman, H.P., Bennett, G.J., Ribeiro-da-Silva, A., Binik, Y.M., and Mogil, J.S.  Repeated vulvovaginal fungal infections cause persistent pain in a mouse model of vulvodynia.  Science Translational Medicine, 3:101ra91, 2011. 
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  • Sotocinal, S.G., Sorge, R.E., Zaloum, A., Tuttle, A.H., Martin, L.J., Wieskopf, J.S., Mapplebeck, J.C.S., Wei, P., Zhan, S., Zhang, S., McDougall, J.J., King, O.D., and Mogil, J.S. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions.  Molecular Pain, 7:55, 2011.** 
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  • LaCroix-Fralish, M.L., Austin, J.-S., Zhang, F.Y., Levitin, D.J., and Mogil, J.S.  Patterns of pain: meta-analysis of microarray studies of pain.  Pain, 152:1888-1898, 2011.**
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  • Langford, D.J., Tuttle, A.H., Briscoe, C., Harvey-Lewis, C., Baran, I., Gleeson, P., Fischer, D.B., Buonora, M., Sternberg, W.F., and Mogil, J.S. Varying perceived social threat modulates pain behavior in male mice.  Journal of Pain, 12:125-132, 2011. 
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  • Fortin, A., Diez, E., Ritchie, J., Sotocinal, S.G., Dube, M.-P., Gagne, M., Paquette, O., Skamene, E., and Mogil, J.S. Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1 (tyrosinase-related protein 1).  Genes, Brain and Behavior, 9:856-867, 2010. 
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  • Mogil, J.S., Graham, A.C., Ritchie, J., Hughes, S.F., Austin, J.-S., Schorscher-Petcu, A., Langford, D.J., and Bennett, G.J. Hypolocomotion, asymmetrically directed behaviors (licking, lifting, flinching, and shaking) and dynamic weight bearing (gait) changes are not measures of neuropathic pain in mice.  Molecular Pain, 6:34, 2010.*
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  • Schorscher-Petcu, A., Sotocinal, S.G., Ciura, S., Dupre, A., Ritchie, J., Sorge, R.E., Crawley, J.N., Hu, S.-B., Nishimori, K., Young, L.J., Tribollet, E., Quirion, R., and Mogil, J.S. Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse.  Journal of Neuroscience, 30:8274-8284, 2010.** 
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  • Langford, D.J., Bailey, A.L., Chanda, M.L., Clarke, S.E., Drummond, T.E., Echols, S., Glick, S., Ingrao, J., Klassen-Ross, T., LaCroix-Fralish, M.L., Matsumiya, L., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wong, D., van den Maagdenberg, A.M.J.M., Ferrari, M.D., Craig, K.D., and Mogil, J.S. Coding of facial expressions of pain in the laboratory mouse.  Nature Methods, 7:447-449, 2010.*** 
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  • Li, X., Sahbaie, P., Zheng, M., Ritchie, J., Peltz, G., Mogil, J.S., and Clark, J.D. Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors.  Molecular Pain, 6:11, 2010.
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  • Malfait, A.-M., Ritchie, J., Gil, A.S., Austin, J.-S., Hartke, J., Qin, W., Tortorella, M.D., and Mogil, J.S.  ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.  Osteoarthrits & Cartilage, 18:572-580, 2010.* 
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  • Juni, A., Cai, M., Stankova, M., Waxman, A.R., Arout, C., Klein, G., Dahan, A., Hruby, V.J., Mogil, J.S., and Kest, B.  Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor.  Anesthesiology, 112:181-188, 2010.*   
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  • Langford, D.J., Tuttle, A.H., Brown, K., Deschenes, S., Fischer, D.B., Mutso, A., Root, K.C., Sotocinal, S.G., Stern, M.A., Mogil, J.S., and Sternberg, W.F.  Social approach to pain in laboratory mice.  Social Neuroscience, 5:163-170, 2010. 
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  • Kest, B., Smith, S.B., Schorscher-Petcu, A., Austin, J.-S., Ritchie, J., Klein, G., Rossi, G.C., Fortin, A., and Mogil, J.S.  Gnao1 (Galphao protein) is a likely genetic contributor to variation in physical dependence on opioids in mice.  Neuroscience, 162:1255-1264, 2009. 
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  • LaCroix-Fralish, M.L., Mo, G., Smith, S.B., Sotocinal, S.G., Ritchie, J., Austin, J.-S., Melmed, K., Schorscher-Petcu, A., Laferriere, A., Lee, T.H., Romanovsky, D., Liao, G., Behlke, M.A., Clark, J.D., Peltz, G., Seguela, P., Dobretsov, M., and Mogil, J.S.  The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.  Pain, 144:294-302, 2009.* 
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  • Schorscher-Petcu, A., Austin, J.-S., Mogil, J.S., and Quirion, R. Role of central calcitonin gene-related peptide (CGRP) in locomotor, anxiety- and depression-like behaviors in two mouse strains exhibiting a CGRP-dependent difference in thermal pain sensitivity.  Journal of Molecular Neuroscience, 39:125-136, 2009.
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  • Mogil, J.S., Simmonds, K., and Simmonds, M.J. Pain research from 1975-2007: a categorical and bibliometric meta-trend analysis of every Research Paper published in the journal, Pain.  Pain, 142:48-58, 2009.*
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  • Loggia, M.L., Bushnell, M.C., Tetreault, M., Thiffault, I., Bherer, C., Mohammed, N.K., Kuchinad, A.A., Laferriere, A., Dicaire, M.-J., Mogil, J.S., and Brais, B.  Carriers of recessive WKN/HSN2mutations for hereditary sensory and autonomic neuropathy type 2 (HSAN2) are more sensitive to thermal stimuli.  Journal of Neuroscience, 29:2162-2166, 2009.
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  • Loggia, M.L., Mogil, J.S., and Bushnell, M.C. Experimentally induced mood changes preferentially affect pain unpleasantness.  Journal of Pain, 9:784-791, 2008.*
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  • Loggia, M.L., Mogil, J.S., and Bushnell, M.C. Empathy hurts: compassion for another increases both sensory and affective components of pain perception.  Pain, 136:168-176, 2008.**
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  • Smith, S.B., Marker, C.L., Perry, C., Liao, G., Sotocinal, S.G., Austin, J.-S., Melmed, K., Clark, D.J., Peltz, G., Wickman, K., and Mogil, J.S. Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes.  Pharmacogenetics and Genomics, 18:231-242, 2008.* 
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  • Callahan, B.L., Gil, A.S.C., Levesque, A., and Mogil, J.S.  Modulation of mechanical and thermal nociceptive sensitivity in the laboratory mouse by behavioral state. Journal of Pain, 9:174-184, 2008.* 
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  • Zhang, J., Shi, X.Q., Echeverry, S., Mogil, J.S., De Koninck, Y., and Rivest, S. Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain.  Journal of Neuroscience, 27:12396-12406, 2007.***
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  • Mogil, J.S., Ritchie, J., Sotocinal, S.G., Smith, S.B., Croteau, S., Levitin, D.J., and Naumova, A.K. Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays.  Pain, 126:24-34, 2006.*
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  • Langford, D.J., Crager, S.E., Shehzad, Z., Smith, S.B., Sotocinal, S.G., Levenstadt, J.S., Chanda, M.L., Levitin, D.J., and Mogil, J.S.  Social modulation of pain as evidence for empathy in mice. Science, 312:1967-1970, 2006.*** 
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  • Chanda, M.L. and Mogil, J.S.  Sex differences in the effects of amiloride on formalin test nociception in mice.  American Journal of Physiology (Regulatory, Integrative and Comparative Physiology), 291:R335-342, 2006.
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  • Green, A.D., Young, K.K., Lehto, S.G., Smith, S.B., and Mogil, J.S. Influence of genotype, dose and sex on pruritogen-induced scratching behavior in mice.  Pain, 124:50-58, 2006.* 
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  • Mogil, J.S., Breese, N.M., Witty, M.-F., Ritchie, J., Rainville, M.-L., Ase, A., Abbadi, N., Stucky, C.L., and Seguela, P. Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. Journal of Neuroscience, 25:9893-9901, 2005.** 
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  • Mogil, J.S., Smith, S.B., O'Reilly, M.K., and Plourde, G. Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains. Anesthesiology, 103:751-758, 2005. 
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  • Mogil, J.S., Miermeister, F., Seifert, F., Strasburg, K., Zimmermann, K., Reinold, H., Austin, J.-S., Bernardini, N., Chesler, E.J., Hofmann, H.A., Hordo, C., Messlinger, K., Nemmani, K.V., Rankin, A.L., Ritchie, J., Siegling, A., Smith, S.B., Sotocinal, S., Vater, A., Lehto, S.G., Klussmann, S., Quirion, R., Michaelis, M., Devor, M., and Reeh, P.W.  Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proceedings of the National Academy of Sciences, U.S.A., 102:12938-12943, 2005.**
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  • LaCroix-Fralish, M.L., Rutkowski, M.D., Weinstein, J.N., Mogil, J.S., and DeLeo, J.A. The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex. Spine, 30:1821-1827, 2005.*
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  • Mogil, J.S., Ritchie, J., Smith, S.B., Strasburg, K., Kaplan, L., Wallace, M.R., Romberg, R.R., Bijl, H., Sarton, E.Y., Fillingim, R.B., and Dahan, A. Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. Journal of Medical Genetics, 42:583-587, 2005.***
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  • Nemmani, K.V.S., Lalonde, J., and Mogil, J.S. Region-specific changes of CaMKIV in the mouse brain following chronic morphine treatment.  Neuroreport, 16:879-882, 2005.
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  • Fillingim, R.B., Kaplan, L., Staud, R., Ness, T.J., Glover, T.L., Campbell, C.M., Mogil, J.S., and Wallace, M.R. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. Journal of Pain, 6:159-167, 2005.***
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  • Sternberg, W.F., Chesler, E.J., Wilson, S.G., and Mogil, J.S. Acute progesterone can recruit sex-specific neurochemical mechanisms mediating swim stress-induced and kappa-opioid analgesia in mice. Hormones and Behavior, 46:467-473, 2004. 
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  • Kest, B., Palmese, C.A., Juni, A., Chesler, E.J., and Mogil, J.S. Mapping of a quantitative trait locus for morphine withdrawal severity. Mammalian Genome, 15:610-617, 2004. 
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  • Sternberg, W.F., Ritchie, J., and Mogil, J.S. Qualitative sex differences in kappa-opioid analgesia in mice are dependent on age. Neuroscience Letters, 363:178-181, 2004. 
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  • Nemmani, K.V.S., Grisel, J.E., Stowe, J.R., Smith-Carliss, R., and Mogil, J.S. Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. Pain, 109:274-283, 2004.**
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  • Smith, S.B., Crager, S.E., and Mogil, J.S. Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains. Life Sciences, 74:2593-2604, 2004.* 
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  • Chesler, E.J., Ritchie, J., Kokayeff, A., Lariviere, W.R., Wilson, S.G., and Mogil, J.S. Genotype-dependence of gabapentin and pregabalin sensitivity: the pharmacogenetic mediation of analgesia is specific to the type of pain being inhibited. Pain, 106:325-335, 2003.* 
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  • Bon, K., Lichtensteiger, C.A., Wilson, S.G., and Mogil, J.S. Characterization of cyclophosphamide cystitis, a model of visceral and referred pain, in the mouse: species and strain differences.Journal of Urology, 170:1008-1012, 2003.* 
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  • Wilson, S.G., Bryant, C.D., Lariviere, W.R., Olsen, M.S., Giles, B.E., Chesler, E.J., and Mogil, J.S. The heritability of antinociception II: pharmacogenetic mediation of three over-the-counter analgesics in mice. Journal of Pharmacology and Experimental Therapeutics, 305:755-764, 2003.* 
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  • Mogil, J.S., Wilson, S.G., Chesler, E.J., Rankin, A.J., Nemmani, K.V.S., Lariviere, W.R., Groce, M.K., Wallace, M.R., Kaplan, L., Staud, R., Ness, T.J., Glover, T.L., Stankova, M., Mayorov, A., Hruby, V.J., Grisel, J.E., and Fillingim, R.B. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proceedings of the National Academy of Sciences, U.S.A., 100:4867-4872, 2003.*** 
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  • Nemmani, K.V.S. and Mogil, J.S. Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia. Neuropharmacology, 44:304-310, 2003.* 
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  • Wilson, S.G., Smith, S.B., Chesler, E.J., Melton, K.A., Haas, J.J., Mitton, B., Strasburg, K., Hubert, L., Rodriguez-Zas, S.L., and Mogil, J.S. The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics. Journal of Pharmacology and Experimental Therapeutics, 304:547-559, 2003.** 
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  • Chesler, E.J., Wilson, S.G., Lariviere, W.R., Rodriguez-Zas, S.L., and Mogil, J.S. Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive. Neuroscience and Biobehavioral Reviews, 26:907-923, 2002.*** 
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  • Kest, B., Palmese, C.A., Hopkins, E., Adler, M., Juni, A., and Mogil, J.S. Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence. Neuroscience, 115:463-469, 2002.** 
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  • Chesler, E.J., Wilson, S.G., Lariviere, W.R., Rodriguez-Zas, S.L., and Mogil, J.S. Influences of laboratory environment on behavior. Nature Neuroscience, 5:1101-1102, 2002.***
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  • Kest, B., Hopkins, E., Palmese, C.A., Adler, M., and Mogil, J.S. Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains. Pharmacology, Biochemistry & Behavior, 73:821-828, 2002.** 
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  • Bon, K., Wilson, S.G., Mogil, J.S., and Roberts, W.J. Genetic evidence for the correlation of deep dorsal horn Fos protein immunoreactivity with tonic formalin pain behavior. Journal of Pain, 3:181-189, 2002.* 
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  • Lariviere, W.R., Wilson, S.G., Laughlin, T.M., Kokayeff, A., West, E.E., Adhikari, S.M., Wan, Y., and Mogil, J.S. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain, 97:75-86, 2002.*** 
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  • Wilson, S.G., Chesler, E.J., Hain, H., Rankin, A.J., Schwarz, J.Z., Call, S.B., Murray, M.R., West, E.E., Teuscher, C., Rodriguez-Zas, S., Belknap, J.K., and Mogil, J.S. Identification of quantitative trait loci for chemical/inflammatory nociception in mice. Pain, 96:385-391, 2002.* 
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  • Chesler, E.J., Rodriguez-Zas, S., and Mogil, J.S. In silico mapping of mouse quantitative trait loci. Science, 294:2423, 2001. (technical comment) 
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  • Rizzi, A., Marzola, G., Bigoni, R., Guerrini, R., Salvadori, S., Mogil, J.S., Regoli, D., and Calo', G. Endogenous nociceptin signaling and stress-induced analgesia. Neuroreport, 12:3009-3013, 2001.* 
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  • Bergeson, S.E., Helms, M.L., O'Toole, L.A., Jarvis, M.W., Hain, H.S., Mogil, J.S. and Belknap, J.K. Quantitative trait loci influencing morphine antinociception in four mapping populations. Mammalian Genome, 12:546-553, 2001.** 
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  • Kest, B., Hopkins, E., Palmese, C.A., Chen, Z.-P., Mogil, J.S., and Pintar, J.E. Morphine tolerance and dependence in nociceptin/orphanin FQ transgenic knock-out mice. Neuroscience, 104:217-222, 2001.* 
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  • Wan, Y., Wilson, S.G., Han, J.S., and Mogil, J.S. The effect of genotype on sensitivity to electroacupuncture analgesia. Pain, 91:5-13, 2001.* 
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  • Mogil, J.S., Grisel, J.E., Bales, J.R., Hayward, M.D., Rubinstein, M., Belknap, J.K., and Low, M. Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience, 101:709-717, 2000. 
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  • Mogil, J.S., Chesler, E.J., Wilson, S.G., Juraska, J.M., and Sternberg, W.F. Sex differences in thermal nociception and morphine antinociception in the rodent depend on genotype.Neuroscience and Biobehavioral Reviews, 24:375-389, 2000.*** 
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  • Flores, C.M, Wilson, S.G., and Mogil, J.S. Pharmacogenetic variability in neuronal nicotinic receptor-mediated antinociception. Pharmacogenetics, 9:619-625, 1999.* 
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  • Hain, H., Belknap, J.K., and Mogil, J.S. Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity. Journal of Pharmacology and Experimental Therapeutics, 291:444-449, 1999.* 
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  • Mogil, J.S. and Adhikari, S. Hot and cold nociception are genetically correlated. Journal of Neuroscience, 19:RC25 (1-5), 1999.* 
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  • Grisel, J.E., Mogil, J.S., Grahame, N.J., Rubinstein, M., Belknap, J.K., Crabbe, J.C., and Low, M. Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression. Brain Research, 835:62-67, 1999.** 
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  • Kest, B., Wilson, S.G., and Mogil, J.S. Sex differences in supraspinal morphine analgesia are dependent on genotype. Journal of Pharmacology and Experimental Therapeutics, 289:1370-1375, 1999.*** 
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  • Martìnez, V., Thakur, S., Mogil, J.S., Tachë, Y., and Mayer, E.A. Differential effects of chemical and mechanical colonic irritation on behavioral pain response to intraperitoneal acetic acid in mice. Pain, 81:179-186, 1999.* 
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  • Mogil, J.S., Wilson, S.G., Bon, K., Lee, S.E., Chung, K., Raber, P., Pieper, J.O., Hain, H.S., Belknap, J.K., Hubert, L., Elmer, G.I., Chung, J.M., and Devor, M. Heritability of nociception. II. 'Types' of nociception revealed by genetic correlation analysis. Pain, 80:83-93, 1999.*** 
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  • Mogil, J.S., Wilson, S.G., Bon, K., Lee, S.E., Chung, K., Raber, P., Pieper, J.O., Hain, H.S., Belknap, J.K., Hubert, L., Elmer, G.I., Chung, J.M., and Devor, M. Heritability of nociception. I. Responses of eleven inbred mouse strains on twelve measures of nociception. Pain, 80:67-82, 1999.*** 
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  • Mogil, J.S., Nessim, L.A., and Wilson, S.G. Strain-dependent effects of supraspinal orphanin FQ/nociceptin on thermal nociceptive sensitivity in mice. Neuroscience Letters, 261:147-150, 1999.* 
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  • Kest, B., Jenab, S., Brodsky, M., Sadowski, B., Belknap, J.K., Mogil, J.S., and Inturrisi, C.E. Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia. Brain Research, 816:381-389, 1999.* 
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  • Kest, B., McLemore, G.L., Sadowski, B., Mogil, J.S., Belknap, J.K., and Inturrisi, C.E. Acute morphine dependence in mice selectively-bred for high and low analgesia. Neuroscience Letters, 256:120-122, 1998. 
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  • Sufka, K.J., Watson, G.S., Nothdurft, R.E., and Mogil, J.S. Scoring the mouse formalin test: validation study. European Journal of Pain, 2:351-358, 1998.* 
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  • Kest, B., Beckzowska, I., Franklin, S.O., Lee, C.E., Mogil, J.S., and Inturrisi, C.E. Differences in delta opioid receptor antinociception, binding, and mRNA levels between BALB/c and CXBK mice. Brain Research, 805:131-137, 1998. 
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  • Grisel, J.E., Farrier, D.E., Wilson, S.G., and Mogil, J.S. [Phe1Y(CH2-NH)Gly2] nociceptin-(1-13)-NH2 acts as an agonist of the orphanin FQ/nociceptin receptor in vivoEuropean Journal of Pharmacology, 357:1-3, 1998.* 
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  • Mogil, J.S., Lichtensteiger, C.A., and Wilson, S.G. The effect of genotype on sensitivity to inflammatory nociception: characterization of resistant (A/J) and sensitive (C57BL/6J) inbred mouse strains. Pain, 76:115-125, 1998.* 
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  • Mogil, J.S., Shin, Y.-H., McCleskey, E.W., Kim, S.-C., and Nah, S.-Y. Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice. Brain Research, 792:218-228, 1998.* 
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  • Mogil, J.S. and Wilson, S.G. Nociceptive and morphine antinociceptive sensitivity of 129 and C57BL/6 inbred mouse strains: implications for transgenic knock-out studies. European Journal of Pain, 1:293-297, 1997.* 
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  • Mogil, J.S., Richards, S.P., O'Toole, L.A., Mitchell, S.R., Helms, M.L., Kest, B., and Belknap, J.K. Identification of sex-specific quantitative trait loci mediating non-opioid swim stress-induced analgesia in female mice. Journal of Neuroscience, 17:7995-8002, 1997.** 
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  • Tian, J.-H., Xu, W., Fang, Y., Grisel, J.E., Mogil, J.S., Grandy, D.K., and Han, J.-S. Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia. Neuroreport, 8:497-500, 1997.** 
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  • Mogil, J.S., Richards, S.P., O'Toole, L.A., Helms, M.L., Mitchell, S.R., and Belknap, J.K. Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by delta2-opioid receptors. Pain, 70:267-277, 1997.** 
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  • Tian, J.-H., Xu, W., Fang, Y., Mogil, J.S., Grisel, J.E., Grandy, D.K., and Han, J.-S. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. British Journal of Pharmacology, 120:676-680, 1997.*** 
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  • Kest, B., Lee, C.E., Mogil, J.S., and Inturrisi, C.E. Blockade of morphine supersensitivity by an antisense oligodeoxynucleotide targeting the DOR-1 delta opioid receptor. Life Sciences, 60:PL155-159, 1997. 
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  • Mogil, J.S. and Belknap, J.K. Sex and genotype determine the selective activation of neurochemically-distinct forms of swim stress-induced analgesia. Pharmacology, Biochemistry & Behavior, 56:61-66, 1997.** 
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  • Mogil, J.S., Grisel, J.E., Zhang, G., Belknap, J.K., and Grandy, D.K. Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ. Neuroscience Letters, 214:131-134, 1996.*** 
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  • Grisel, J.E., Mogil, J.S., Belknap, J.K., and Grandy, D.K. Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. Neuroreport, 7:2125-2129, 1996.*** 
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  • Mogil, J.S., Grisel, J.E., Reinscheid, R.K., Civelli, O., Belknap, J.K., and Grandy, D.K. Orphanin FQ is a functional anti-opioid peptide. Neuroscience, 75:333-337, 1996.***
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  • Rubinstein, M.†, Mogil, J.S.†, Japón, M., Chan, E.C., Allen, R.G., and Low, M.J. Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis.Proceedings of the National Academy of Sciences, U.S.A., 93:3995-4000, 1996.***    (†these authors contributed equally to this manuscript) 
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  • Mogil, J.S., Kest, B., Sadowski, B., and Belknap, J.K. Differential genetic mediation of sensitivity to morphine in genetic models of opiate sensitivity: influence of nociceptive assay. Journal of Pharmacology and Experimental Therapeutics, 276:532-544, 1996.*** 
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  • Mogil, J.S., Sternberg, W.F., Balian, H., Liebeskind, J.C., and Sadowski, B. Opioid and non-opioid swim stress-induced analgesia: a parametric analysis in mice. Physiology & Behavior, 59:123-132, 1996.** 
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  • Kest, B., Brodsky, M., Sadowski, B., Mogil, J.S., and Inturrisi, C.E. Mu-opiate receptor (Mor-1) mRNA levels are altered in mice with differential analgesic sensitivity to the mu agonist, DAMGO. Analgesia, 1:498-501, 1995.  

  • Sternberg, W.F., Mogil, J.S., Kest, B., Page, G.G., Leong, Y., Yam, V., and Liebeskind, J.C. Neonatal testosterone exposure influences neurochemistry of swim stress-induced analgesia in adult mice. Pain, 63:321-326, 1995.* 
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  • Vaccarino, F.J., Mogil, J.S., and Stinus, L. Chronic dopamine antagonism facilitates opiate-induced feeding. Journal of Psychiatry and Neuroscience, 20:210-214, 1995. 
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  • Mogil, J.S., Flodman, P., Spence, M.A., Sternberg, W.F., Kest, B., Sadowski, B., Liebeskind, J.C., and Belknap, J.K. Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines. Behavior Genetics, 25:397-406, 1995. 
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  • Kest, B., Mogil, J.S., Sternberg, W.F., Pechnick, R.N., and Liebeskind, J.C. 1,3-di-o-tolylguanidine (DTG) differentially affects acute and tonic formalin pain: antagonism by rimcazole.Pharmacology, Biochemistry & Behavior, 52:175-178, 1995. 
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  • Belknap, J.K., Mogil, J.S., Helms, M.L., O'Toole, L.A., Richards, S.P., and Bergeson, S.E. Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 mouse strains. Life Sciences, 57:PL117-124, 1995.** 
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  • Kest, B., Mogil, J.S., Sternberg, W.F., Pechnick, R.N., and Liebeskind, J.C. Antinociception following 1,3-di-o-tolylguanidine (DTG), a selective sigma receptor ligand. Pharmacology, Biochemistry & Behavior, 50:587-592, 1995. 
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  • Mogil, J.S., Marek, P., Flodman, P., Spence, M.A., Sternberg, W.F., Kest, B., Sadowski, B., and Liebeskind, J.C. One or two genetic loci mediate high opiate analgesia in selectively bred mice.Pain, 60:125-135, 1995.* 
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  • Mogil, J.S., Marek, P., O'Toole, L.A., Helms, M.L., Sadowski, B., Liebeskind, J.C., and Belknap, J.K. Mu-opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia. Brain Research, 653:16-22, 1994.* 
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  • Mogil, J.S., Sternberg, W.F., Kest, B., Marek, P., and Liebeskind, J.C. Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement. Pain, 253:17-25, 1993.*** 
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  • Marek, P., Mogil, J.S., Belknap, J.K., Sadowski, B., and Liebeskind, J.C. Levorphanol and swim stress-induced analgesia in selectively bred mice: evidence for genetic commonalties. Brain Research, 608:353-357, 1993.* 
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  • Mogil, J.S., Marek, P., Yirmiya, R., Balian, H., Sadowski, B., Taylor, A.N., and Liebeskind, J.C. Antagonism of the non-opioid component of ethanol-induced analgesia by the NMDA receptor antagonist MK-801. Brain Research, 602:126-130, 1993. 
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  • Marek, P., Mogil, J.S., Sternberg, W.F., Panocka, I., and Liebeskind, J.C. N-Methyl-D-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia. II. Studies using three different water temperature paradigms and selectively bred mice. Brain Research, 578:197-203, 1992.** 
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  • Ben-Eliyahu, S., Marek, P., Vaccarino, A.L., Mogil, J.S., Sternberg, W.F., and Liebeskind, J.C. The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat. Brain Research, 575: 304-308, 1992.*** 
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Department of Psychology 
McGill University 
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